Immune Support
Digestive Support
Shelf-stable Simplicity
Postbiotics are one of the fastest-growing frontiers in gut-health and immune-support nutrition. Consumers and formulators want microbiome-related benefits without the instability of probiotics or the GI distress often experienced with clinically efficacious servings of many prebiotics.
A protein-derived postbiotic, built for formulators.
Thryvia is a protein-derived postbiotic ingredient to provide immune and digestive support. It is produced from heat-killed, non-viable Clostridium tyrobutyricum (strain ASM#19) and is not a live probiotic, nor is it dependent on organism viability for activity.
A comprehensive safety package — toxicology, genotoxicity, allergenicity, exposure modeling, and human tolerability data — underpins its FDA GRAS status, discussed in full below.
No risk of organism growth — or worse, death.
Because the organism has already produced its metabolites during fermentation, the benefit does not depend on keeping cells alive through processing, storage, or digestion — all the benefits of a great probiotic, without the probiotic challenges.
Natural Immune Signaling
Precision postbiotic activity supporting immune and digestive health.
Shelf-stable Formulation Freedom
No refrigeration, no viability loss, compatible with virtually any delivery format — including clear, shelf-stable beverages.
Shelf-stable by Design
No cold chain required. Compatible with UHT-processed shelf-stable beverages and a broad range of pH conditions, reducing distribution costs while expanding formulation flexibility.
Thryvia Postbiotic vs Probiotics
Consumers choose Thryvia.
Thryvia does not just perform in the lab. Blinded consumer research and an early perception study show it resonates with the people who buy your products, connecting the scientific and the commercial opportunity.
Built to Compete with Category Leaders
In blinded consumer research, Thryvia branding and messaging outperformed established postbiotic brands among U.S. supplement users.
Thryvia was preferred over the leading postbiotic brand head to head, and outperformed the next three leading brands by even wider margins.
More Inspiring Brand
“Build. Balance. Thrive.” resonated as proactive and aspirational.
Double the Health Benefit
Consumers valued support for both digestive and immune health.
Modern, Premium Identity
Distinctive branding while maintaining clinical credibility.
In a decentralized perception study, consumers reported meaningful digestive improvements.
reported less digestive discomfort after consuming dairy products
said their stomach felt more at ease throughout the day
reported less abdominal discomfort or cramping
Group-average scores improved across every measured digestive outcome from baseline through Week 1, suggesting continued improvement throughout the remainder of the four-week study.
More ease. More confidence. More room to enjoy the day.
reported more enjoyable mealtimes
felt generally more comfortable day to day
felt more confident eating away from home
Consumer-reported outcomes from a decentralized perception study and a blinded consumer preference survey. Perceptions are self-reported and are not a measure of clinical efficacy.
Thryvia science, in human terms.
Independent research spanning mechanism, translation, human studies, and safety.
Third-party, preclinical research demonstrates targeted activation of innate immune receptors (TLR2, TLR5, and NOD2), establishing a defined mechanism for immune and digestive health.
Controlled animal studies confirm these immune signals translate into meaningful biological outcomes, including improved immune resilience and pathogen resistance.
Human studies evaluating digestive health, consumer-reported outcomes, and nutritional performance continue to expand the clinical evidence supporting Thryvia.
A comprehensive safety package including toxicology, genotoxicity, allergenicity, exposure modeling, and human tolerability, which underpins FDA GRAS No Questions Letter.
Evidence-based label claims.
Current marketing claims supported by Thryvia's clinical, preclinical, and mechanistic evidence:
Human studies
- Clinically studied to support digestive health.
- Clinically studied to support general wellness.
Preclinical research
- Preclinically demonstrated to support innate immune function.
- Preclinically demonstrated to support digestive and immune health.
- Preclinically demonstrated to improve immune resilience.
- Preclinically demonstrated targeted innate immune signaling.
Mechanism of action
- Precision postbiotic with a preclinically demonstrated mechanism of action.
Continued clinical studies support a growing portfolio of label claims.
FDA GRAS confirmed, with expanding regulatory support for global markets.
FDA GRAS confirmed (GRN 1129), supporting broad use across food and dietary supplement applications.
Clostridium tyrobutyricum has been recommended by EFSA experts for inclusion on the Qualified Presumption of Safety (QPS) list.
EFSA Novel Food and UK FSA safety evaluations are underway to support commercialization in Europe and the United Kingdom.
The GRAS filing establishes Thryvia’s safety as a food ingredient. Specific immune-support, digestive-support, or postbiotic health claims require separate claims substantiation beyond the GRAS filing.
Three categories. One formulation-friendly ingredient.
Low inclusion, shelf-stability, and broad pH and thermal tolerance mean Thryvia formulates into virtually any food, beverage, supplement, or companion animal product — without the cold chain, viability protection, or specialized handling live probiotics require.
Dietary Supplements
- Dual benefit, one ingredient. Supports digestive health and everyday wellness through natural immune signaling.
- High potency, formulation flexibility. A low inclusion rate eases formulation while delivering meaningful biological activity.
- Broad format compatibility. Capsules, powders, stick packs, liquids, chews, and functional foods.
- Shelf-stability means manufacturing simplicity. No refrigeration, viability protection, or specialized handling. Can be considered for formats like UHT, where probiotics are not possible.
- Launch-ready support. Formulation guidance and prototypes through co-packers, labeling, and commercial scale-up.
Functional Food & Beverage
- Everyday wellness through everyday foods. Supports digestive health and everyday wellness through natural immune signaling.
- Low inclusion, formulation freedom. A low inclusion rate eases formulation while delivering meaningful biological activity.
- Shelf-stability means manufacturing simplicity. Compatible with conventional food processing, including UHT where probiotics are often impractical.
- Broad food compatibility. Dairy, beverages, bars, cereals, snacks, frozen desserts, and more.
- Launch-ready support. Prototype development and formulation guidance through co-packers and commercial scale-up.
Companion Animal Products
- Gut health and immune resilience. Naturally supports digestive health and everyday wellness in dogs and cats through natural immune signaling.
- High potency, formulation flexibility. Low inclusion minimizes formulation cost and easily integrates into treats, toppers, supplements, and complete diets.
- Shelf-stability means commercial simplicity. No refrigeration, viability protection, or specialized handling required. Compatible with conventional extrusion processes.
- Broad format compatibility. Suitable for soft chews, functional treats, powders, toppers, capsules, wet foods, and dry kibble.
- Commercial-ready support. Formulation guidance, co-manufacturing support, and commercialization assistance.
The next generation of digestive and immune wellness starts here.
Category-Defining
A postbiotic ingredient positioned ahead of the growth curve.
Manufacturing Scale
Reliability through our manufacturing partnership with Döhler, providing scalable supply for customer programs worldwide.
Regulatory Groundwork Done
GRAS clearance already in place, shortening your path to launch.
Flexible Formulation Support
Across supplement, food & beverage, and pet categories.
Low Cannibalization
Extend existing gut-health and immune lines rather than compete with them.
Shelf-Stable Logistics
Room-temperature stable, no cold-chain investment required.
Ready to formulate.
Ready to scale.
Ready to launch.
Commercial supply is available today, supported by formulation, regulatory, and commercialization expertise.
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